At a glance
Borderlands 2 has a Mac version: Steam sells it for macOS. The Mac requirements list only Intel: on Apple Silicon Rosetta 2 runs it, and old Mac versions sometimes do not start on current macOS. Try it in Steam for Mac first.
Borderlands 2 came out on Steam on 17 September 2012, made by Gearbox Software.
Mac version by Aspyr.
What your Mac needs
The Mac requirements list only Intel.
Minimum macOS in the Steam requirements: 10.12.
Steam requirements list at least 4 GB of memory for Borderlands 2.
Allow about 13 GB of disk space for the Mac version.
How to play
Open Steam for Mac and install Borderlands 2 as usual.
If the Mac version will not start, you can install the Windows version through Uncork: download Uncork, sign in to Steam and install Borderlands 2 from there (13 GB). We have not tested it ourselves.
The Windows version through Uncork needs a Mac with Apple Silicon (M1 or newer).