At a glance
Path of Exile has a Mac version: Steam sells it for macOS. The Mac requirements list only Intel: on Apple Silicon Rosetta 2 runs it, and old Mac versions sometimes do not start on current macOS. Try it in Steam for Mac first.
Path of Exile came out on Steam on 23 October 2013, made by Grinding Gear Games.
What your Mac needs
The Mac requirements list only Intel.
Minimum macOS in the Steam requirements: 10.13.
Steam requirements list at least 8 GB of memory for Path of Exile; 16 GB recommended.
Allow about 40 GB of disk space for the Mac version.
How to play
Open Steam for Mac and install Path of Exile as usual.
If the Mac version will not start, you can install the Windows version through Uncork: download Uncork, sign in to Steam and install Path of Exile from there (40 GB). We have not tested it ourselves.
The Windows version through Uncork needs a Mac with Apple Silicon (M1 or newer).
Path of Exile uses DirectX 11: Uncork renders it with D3DMetal.