At a glance
Alien: Isolation has a Mac version: Steam sells it for macOS. The Mac requirements list only Intel: on Apple Silicon Rosetta 2 runs it, and old Mac versions sometimes do not start on current macOS. Try it in Steam for Mac first.
Alien: Isolation came out on Steam on 6 October 2014, made by Creative Assembly.
Mac version by Feral Interactive.
What your Mac needs
The Mac requirements list only Intel.
Minimum macOS in the Steam requirements: 10.10.4.
Steam requirements list at least 4 GB of memory for Alien: Isolation.
Allow about 35 GB of disk space for the Mac version.
How to play
Open Steam for Mac and install Alien: Isolation as usual.
If the Mac version will not start, you can install the Windows version through Uncork: download Uncork, sign in to Steam and install Alien: Isolation from there (35 GB). We have not tested it ourselves.
The Windows version through Uncork needs a Mac with Apple Silicon (M1 or newer).
Alien: Isolation uses DirectX 11: Uncork renders it with D3DMetal.